不同氨基酸結(jié)構(gòu)影響亞鐵螯合能力

氨基酸組成分析顯示，當(dāng)多肽中含有酸性或堿性氨基酸殘基時，其與鐵離子表現(xiàn)出良好的結(jié)合性。Glu 和Asp含有活性側(cè)鏈基團(tuán)，有助于形成肽-金屬復(fù)合物。 例如，Lys、 Asp和Glu中含有羧基、氨基、胍基等，這些側(cè)鏈基團(tuán)通過靜電作用或配位作用，與金屬離子結(jié)合，從而使多肽具有一定的鐵離子結(jié)合能力。Glu 和 Asp因具有環(huán)狀結(jié)構(gòu)，能夠與亞鐵等金屬離子結(jié)合，形成穩(wěn)定的金屬螯合物。有研究發(fā)現(xiàn)，具有較好亞鐵螯合能力的多肽通常還與Cys、Arg、Ser等氨基酸有著緊密的聯(lián)系，可能是小肽和亞鐵離子通過配位鍵、離子鍵的相互作用而形成新的物質(zhì)，螯合反應(yīng)的主要結(jié)合位點(diǎn)是氨基、羧基和肽鍵，谷氨酸（Glu 和 Asp）、天冬氨酸（Asp）和半胱氨酸（Cys）參與了螯合反應(yīng)。

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抗壞血酸亞鐵Ferrous Ascorbate、賴氨酸甘氨酸鎂Magnesium Lysinate Glycinate、甘氨酸谷氨酰胺鎂Magnesium Glycinate Glutamine、檸檬酸蘋果酸鎂Magnesium Citrate Malate、檸檬酸鍶Strontium Citrate、檸檬酸錳Manganese Citrate、檸檬酸銅Copper Citrate、天門冬氨酸鋰Lithium Aspartate、抗壞血酸錳Manganese Ascorbate、牛磺酸硒Selenium Taurate。

Different amino acid structures affect ferrous chelation ability

Amino acid composition analysis showed that when the polypeptide contained acidic or basic amino acid residues, it showed good binding with iron ions. Glu and Asp contain active side chain groups that contribute to the formation of peptide-metal complexes. For example, Lys, Asp and Glu contain carboxyl, amino, guanidine, etc. These side chain groups bind to metal ions through electrostatic interaction or coordination, so that the polypeptide has a certain iron ion binding ability. Because of their ring structure, Glu and Asp can combine with ferrous ions to form stable metal chelates. Some studies have found that peptides with good ferrous chelating ability are usually closely related to amino acids such as Cys, Arg and Ser, which may be due to the interaction of small peptides and ferrous ions through coordination bonds and ionic bonds to form new substances. The main binding sites of chelating reactions are amino, carboxyl and peptide bonds. Glutamic acid (Glu and Asp), aspartate (Asp) and cysteine (Cys) were involved in the chelation reaction.

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Ferrous Ascorbate, Magnesium Lysinate Glycinate, Magnesium lysinate Glycinate Glutamine, Magnesium citrate malate Citrate Malate, Strontium Citrate, Manganese Citrate, Copper Citrate, Lithium Aspartate, Manganese ascorbate Ascorbate, Selenium Taurate.