檸檬酸鋅（Zinc Citrate）對(duì)口腔細(xì)菌和牙菌斑的抑制作用

在口腔護(hù)理領(lǐng)域中，自上世紀(jì)40年代首先發(fā)現(xiàn)含鋅化合物具有抗牙菌斑的作用，能幫助防齲后，檸檬酸鋅等化合物開始被加入牙膏中，幫助實(shí)現(xiàn)控制牙菌斑、緩解牙齦出血牙齦炎、抗牙結(jié)石等功能。按美國食品藥品監(jiān)督管理局對(duì)控制牙菌斑和緩解牙齦炎功效成分的分類，檸檬酸鋅安全等級(jí)為Ⅰ，功效等級(jí)為Ⅲ，是牙膏中一種安全有效的功效成分。活性物檸檬酸鋅，主要是介入牙菌斑生長的第二、三階段，通過抑制口腔細(xì)菌的生長，減少牙菌斑的形成。鋅化合物抗菌機(jī)理較多，主要有鋅離子溶出抗菌學(xué)說、接觸抗菌學(xué)說和納米抗菌學(xué)說等。檸檬酸鋅主要是以鋅離子溶出抗菌學(xué)說為主，溶解的鋅離子與細(xì)菌接觸而產(chǎn)生抗菌作用。鋅離子溶出抗菌可通過:(1) 破壞細(xì)胞膜功能;(2)使細(xì)菌蛋白質(zhì)或酶類變性;(3)進(jìn)入細(xì)菌細(xì)胞內(nèi)的鋅離子也可能與核酸結(jié)合，破壞細(xì)胞的分裂繁殖能力，達(dá)到抑菌和殺菌的目的。基于鋅離子溶出抗菌學(xué)說，許多文獻(xiàn)研究發(fā)現(xiàn)實(shí)際使用含檸檬酸鋅牙膏后，口腔鋅濃度很快就能提高，甚至能保留較長時(shí)間。臨床研究發(fā)現(xiàn)使用牙膏提高口腔鋅濃度的同時(shí)，能有效地抑制口腔細(xì)菌產(chǎn)生，能減少牙菌斑指數(shù)，并且減輕色素沉積。

檸檬酸鋅（Zinc Citrate）對(duì)口腔細(xì)菌和牙菌斑的抑制作用

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Inhibitory effect of zinc citrate on oral bacteria and dental plaque

In the field of oral care, since the 1940s, it was first discovered that zinc-containing compounds have anti-plaque effects and can help prevent caries, zinc citrate and other compounds began to be added to toothpaste to help control dental plaque, relieve gingivitis, gingivitis and other functions. According to the U.S. Food and Drug Administration's classification of plaque control and gingivitis relief ingredients, zinc citrate safety level Ⅰ, efficacy level III, is a safe and effective ingredient in toothpaste. Zinc citrate, the active substance, mainly intervenes in the second and third stages of dental plaque growth, reduces the formation of dental plaque by inhibiting the growth of oral bacteria. There are many antibacterial mechanisms of zinc compounds, including the theory of zinc ion dissolution, contact and nano-antibacterial. Zinc citrate is mainly based on the antibacterial theory of zinc ion dissolution, and the antibacterial effect of dissolved zinc ion is produced by contact with bacteria. Zinc ion leaching can inhibit bacteria by :(1) destroying cell membrane function; (2) denaturation of bacterial proteins or enzymes; (3) Zinc ions entering bacterial cells may also combine with nucleic acids, destroy the cell's ability to divide and multiply, and achieve the purpose of bacteriostasis and sterilization. Based on the antibacterial theory of zinc ion dissolution, many literature studies have found that the oral zinc concentration can be increased quickly after the actual use of toothpaste containing zinc citrate, and even can be retained for a long time. Clinical studies have found that using toothpaste to increase oral zinc concentration can effectively inhibit the production of oral bacteria, reduce dental plaque index, and reduce pigmentation.

Inhibitory effect of zinc citrate on oral bacteria and dental plaque

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Magnesium Taurate、Calcium Amino Acid Chelate、Magnesium Glutamate、Zinc Lysinate、 L-Isoleucine、Copper Glycinate、Potassium Gluconate、Calcium Malate、Magnesium Ascorbate、Magnesium Orotate