檸檬酸鋅（Zinc Citrate）對口腔細菌和牙菌斑的抑制作用

在口腔護理領域中，自上世紀40年代首先發(fā)現(xiàn)含鋅化合物具有抗牙菌斑的作用，能幫助防齲后，檸檬酸鋅等化合物開始被加入牙膏中，幫助實現(xiàn)控制牙菌斑、緩解牙齦出血牙齦炎、抗牙結(jié)石等功能。按美國食品藥品監(jiān)督管理局對控制牙菌斑和緩解牙齦炎功效成分的分類，檸檬酸鋅安全等級為Ⅰ，功效等級為Ⅲ，是牙膏中一種安全有效的功效成分。活性物檸檬酸鋅，主要是介入牙菌斑生長的第二、三階段，通過抑制口腔細菌的生長，減少牙菌斑的形成。鋅化合物抗菌機理較多，主要有鋅離子溶出抗菌學說、接觸抗菌學說和納米抗菌學說等。檸檬酸鋅主要是以鋅離子溶出抗菌學說為主，溶解的鋅離子與細菌接觸而產(chǎn)生抗菌作用。鋅離子溶出抗菌可通過:(1) 破壞細胞膜功能;(2)使細菌蛋白質(zhì)或酶類變性;(3)進入細菌細胞內(nèi)的鋅離子也可能與核酸結(jié)合，破壞細胞的分裂繁殖能力，達到抑菌和殺菌的目的。基于鋅離子溶出抗菌學說，許多文獻研究發(fā)現(xiàn)實際使用含檸檬酸鋅牙膏后，口腔鋅濃度很快就能提高，甚至能保留較長時間。臨床研究發(fā)現(xiàn)使用牙膏提高口腔鋅濃度的同時，能有效地抑制口腔細菌產(chǎn)生，能減少牙菌斑指數(shù)，并且減輕色素沉積。

檸檬酸鋅（Zinc Citrate）對口腔細菌和牙菌斑的抑制作用

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牛磺酸鎂Magnesium Taurate、氨基酸螯合鈣Calcium Amino Acid Chelate、谷氨酸鎂Magnesium Glutamate、賴氨酸鋅Zinc Lysinate、L-異亮氨酸L-Isoleucine、甘氨酸銅Copper Glycinate、葡萄糖酸鉀Potassium Gluconate、蘋果酸鈣Calcium Malate、抗壞血酸鎂Magnesium Ascorbate、乳清酸鎂Magnesium Orotate

Inhibitory effect of zinc citrate on oral bacteria and dental plaque

In the field of oral care, since the 1940s, it was first discovered that zinc-containing compounds have anti-plaque effects and can help prevent caries, zinc citrate and other compounds began to be added to toothpaste to help control dental plaque, relieve gingivitis, gingivitis and other functions. According to the U.S. Food and Drug Administration's classification of plaque control and gingivitis relief ingredients, zinc citrate safety level Ⅰ, efficacy level III, is a safe and effective ingredient in toothpaste. Zinc citrate, the active substance, mainly intervenes in the second and third stages of dental plaque growth, reduces the formation of dental plaque by inhibiting the growth of oral bacteria. There are many antibacterial mechanisms of zinc compounds, including the theory of zinc ion dissolution, contact and nano-antibacterial. Zinc citrate is mainly based on the antibacterial theory of zinc ion dissolution, and the antibacterial effect of dissolved zinc ion is produced by contact with bacteria. Zinc ion leaching can inhibit bacteria by :(1) destroying cell membrane function; (2) denaturation of bacterial proteins or enzymes; (3) Zinc ions entering bacterial cells may also combine with nucleic acids, destroy the cell's ability to divide and multiply, and achieve the purpose of bacteriostasis and sterilization. Based on the antibacterial theory of zinc ion dissolution, many literature studies have found that the oral zinc concentration can be increased quickly after the actual use of toothpaste containing zinc citrate, and even can be retained for a long time. Clinical studies have found that using toothpaste to increase oral zinc concentration can effectively inhibit the production of oral bacteria, reduce dental plaque index, and reduce pigmentation.

Inhibitory effect of zinc citrate on oral bacteria and dental plaque

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Magnesium Taurate、Calcium Amino Acid Chelate、Magnesium Glutamate、Zinc Lysinate、 L-Isoleucine、Copper Glycinate、Potassium Gluconate、Calcium Malate、Magnesium Ascorbate、Magnesium Orotate