L-蘇糖酸鎂(Magnesium-L-threonate)對(duì)人體睡眠的影響

L-蘇糖酸作為維生素C的降解產(chǎn)物，能夠促進(jìn)維生素C的吸收和利用，從而提高其活性，且與胰島素有協(xié)同作用，作為金屬離子的載體可使金屬離子易與氨基酸或蛋白質(zhì)結(jié)合而被動(dòng)物吸收和利用，在人體中具有較高的生理活性。鎂可通過(guò)抑制Na⁺-K⁺-ATP酶及鎂-ATP酶，調(diào)節(jié)中樞神經(jīng)遞質(zhì)如兒茶酚胺、阿片受體及神經(jīng)DNA受體影響中樞神經(jīng)功能及激素對(duì)神經(jīng)功能的調(diào)節(jié)。由于腦脊液內(nèi)鎂離子含量高于血漿，因此單純給予常用的鎂鹽如MgSO₄或MgCl₂，對(duì)于腦內(nèi)鎂離子含量的提高作用甚微。L-蘇糖酸鎂具有很高的生物利用度，通過(guò)飲食補(bǔ)給L-蘇糖酸鎂可以顯著的升高腦內(nèi)的鎂離子水平，通過(guò)提高腦鎂可以增強(qiáng)大鼠的長(zhǎng)短期記憶力，可以防止和恢復(fù)記憶缺陷，改善了學(xué)習(xí)和記憶功能；治療精神分裂癥，對(duì)突觸有保護(hù)作用，可能具有治療阿爾茨海默氏病的潛力。γ-氨基丁酸是哺乳動(dòng)物中樞神經(jīng)系統(tǒng)內(nèi)最重要的氨基酸類神經(jīng)遞質(zhì)，對(duì)神經(jīng)元的活動(dòng)具有抑制作用，在睡眠的調(diào)節(jié)中發(fā)揮著重要的作用，γ-氨基丁酸有促進(jìn)睡眠的生理功能。Mg²⁺可增強(qiáng)γ-氨基丁酸誘發(fā)的電流，通過(guò)正性變構(gòu)調(diào)節(jié)機(jī)制影響 γ-氨基丁酸 A 型受體的功能。 在本實(shí)驗(yàn)中 L-蘇糖酸鎂本身無(wú)催眠作用，但與巴比妥類共同作用，一定條件下能改善睡眠。

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氨基酸螯合鈣Amino acid chelate calcium、抗壞血酸錳Manganese Ascorbate、、賴氨酸甘氨酸鎂Magnesium Lysinate Glycinate、甘氨酸谷氨酰胺鎂Magnesium Glycinate Glutamine、檸檬酸蘋果酸鎂Magnesium Citrate Malate、檸檬酸鍶Strontium Citrate、檸檬酸錳Manganese Citrate、檸檬酸銅Copper Citrate、天門冬氨酸鋰Lithium Aspartate、牛磺酸硒Selenium Taurate

Effects of Magnesium L-threonate on sleep

L-threonic acid, as a degradation product of vitamin C, can promote the absorption and utilization of vitamin C, thereby improving its activity, and has a synergistic effect with insulin. As a carrier of metal ions, metal ions can be easily combined with amino acids or proteins and be absorbed and utilized by animals, and has a high physiological activity in the human body. By inhibiting Na⁺-K⁺-ATPase and magnesium-ATPase, magnesium can regulate central neurotransmitters such as catecholamines, opioid receptors and nerve DNA receptors to affect central nervous function and hormone regulation of nerve function. Since the content of magnesium ions in cerebrospinal fluid is higher than that in plasma, the simple administration of commonly used magnesium salts such as MgSO₄ or MgCl₂ has little effect on the increase of magnesium ion content in brain. Magnesium L-threonate has a high bioavailability. Dietary supplementation of magnesium L-threonate can significantly increase the level of magnesium ion in the brain, enhance the short and long term memory of rats, prevent and restore memory defects, and improve learning and memory functions. Treating schizophrenia, which has a protective effect on synapses, may have potential to treat Alzheimer's disease. Gamma-aminobutyric acid (GAMma-aminobutyric acid) is the most important amino acid neurotransmitter in the central nervous system of mammals. It has inhibitory effect on the activity of neurons and plays an important role in the regulation of sleep. Gamma-aminobutyric acid has the physiological function of promoting sleep. Mg²⁺ can enhance the current induced by gamma-aminobutyric acid and affect the function of gamma-aminobutyric acid type A receptor through positive allosteric regulatory mechanisms. In this experiment, magnesium L-threonate itself has no hypnotic effect, but it can improve sleep under certain conditions by interacting with barbiturates.

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Amino acid chelate calcium, Manganese Ascorbate, Magnesium Lysinate Glycinate, Magnesium lysinate glycinate, magnesium glutamine Glycinate Glutamine, Magnesium Citrate Malate, Strontium Citrate, Manganese Citrate, Copper citrate Citrate, Lithium Aspartate, Selenium Taurate.