銅離子（甘氨酸銅Copper Glycinate、天門冬氨酸銅Copper Aspartate、氨基酸螯合銅Copper Amino Acid Chelate、檸檬酸銅Copper Citrate、葡萄糖酸銅Copper Gluconate）的抗炎作用作用

銅是人體內(nèi)的關(guān)鍵微量元素，在維持人體生理動(dòng)態(tài)平衡和抗菌方面起著至關(guān)重要的作用，與細(xì)胞免疫和體液免疫之間存在一定聯(lián)系。銅離子常被報(bào)道具有良好的抗茵活性，其作為銅藍(lán)蛋白的活性部位，通過(guò)刺激炎癥細(xì)胞因子和低氧誘導(dǎo)因子的合成來(lái)促進(jìn)銅藍(lán)蛋白的合成和分泌。此外，在炎癥、感染和其他疾病的急性期反應(yīng)中，銅的代謝明顯增強(qiáng)，以不同的氧化還原狀態(tài)，使金屬在細(xì)胞生理學(xué)中作為催化輔因子在酶的氧化還原化學(xué)、線粒體呼吸、鐵吸收、自由基清除和彈性蛋白交聯(lián)中發(fā)揮關(guān)鍵作用。銅摻入生物活性玻璃陶瓷構(gòu)造含銅生物活性玻璃陶瓷支架可誘導(dǎo)巨噬細(xì)胞向抗炎表型極化，減少促炎細(xì)胞因子的分泌，顯著促進(jìn)軟骨和骨軟骨界面的再生，對(duì)于缺損組織的修復(fù)與再生具有有益影響，是潛在植入材料候選。釋放的銅離子增加人細(xì)支氣管上皮細(xì)胞分泌白細(xì)胞介素6、白細(xì)胞介素8和白細(xì)胞介素10等炎癥細(xì)胞因子，使腫瘤壞死因子a的分泌顯著減少，調(diào)節(jié)宿主炎癥反應(yīng)。

銅離子（甘氨酸銅Copper Glycinate、天門冬氨酸銅Copper Aspartate、氨基酸螯合銅Copper Amino Acid Chelate、檸檬酸銅Copper Citrate、葡萄糖酸銅Copper Gluconate）的抗炎作用作用

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L-谷氨酰胺L-Glutamine、L-異亮氨酸L-Isoleucine、L-色氨酸L-Tryptophan、甘氨酸鈣Calcium Glycinate、抗壞血酸鋅Zinc Ascorbate、吡啶甲酸鋅Zinc Picolinate、檸檬酸鉀Potassium Citrate、甘氨酸硼Boron Glycinate、氨基酸螯合硒Selenium Amino Acid Chelate、葡萄糖酸鎂Magnesium Gluconate

Anti-inflammatory effect of Copper ions (Copper Glycinate, Copper Aspartate, Copper Amino Acid Chelate, Copper Citrate, Copper Gluconate)

Copper is a key trace element in human body, which plays a vital role in maintaining physiological homeostasis and antibacterial, and has a certain relationship with cellular immunity and humoral immunity. Copper ions have often been reported to have good anti-bacterial activity. As the active site of ceruloplasmin, copper ions promote the synthesis and secretion of ceruloplasmin by stimulating the synthesis of inflammatory cytokines and hypoxy-inducing factors. In addition, during the acute phase response of inflammation, infection, and other diseases, copper metabolism is significantly enhanced in different REDOX states, allowing the metal to play a key role in cellular physiology as a catalytic cofactor in enzyme REDOX chemistry, mitochondrial respiration, iron absorption, free radical clearance, and elastin crosslinking. The bioactive glass ceramic scaffold containing copper can induce the polarization of macrophages towards the anti-inflammatory phenotype, reduce the secretion of pro-inflammatory cytokines, and significantly promote the regeneration of cartilage and osteochondral interface, which has a beneficial effect on the repair and regeneration of defective tissues, and is a potential candidate for implantation materials. The release of copper ions increases the secretion of inflammatory cytokines such as interleukin 6, interleukin 8 and interleukin 10 by human bronchiolar epithelial cells, significantly reduces the secretion of tumor necrosis factor a, and regulates the host inflammatory response.

Anti-inflammatory effect of Copper ions (Copper Glycinate, Copper Aspartate, Copper Amino Acid Chelate, Copper Citrate, Copper Gluconate)

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L-Glutamine；L-Isoleucine；L-Tryptophan；Calcium Glycinate；Zinc Ascorbate；Zinc Picolinate；Potassium Citrate；Boron Glycinate；Selenium Amino Acid Chelate；Magnesium Gluconate；