檸檬酸鈣(Calcium citrate)在機(jī)體的代謝

鈣的吸收主要發(fā)生在小腸，通過旁細(xì)胞通路和維生素D₃調(diào)控的跨細(xì)胞通路2個途徑經(jīng)由跨膜蛋白質(zhì)上Ca²⁺轉(zhuǎn)運載體來完成鈣離子轉(zhuǎn)運。旁細(xì)胞途徑是利用腸道和血液中鈣離子濃度的梯度進(jìn)行被動轉(zhuǎn)運的吸收途徑，不需要消耗ATP；而跨細(xì)胞途徑是鈣離子通過鈣結(jié)合蛋白質(zhì)在相關(guān)酶的作用下依賴維生素D₃而被機(jī)體主動吸收的一個過程，此過程需要消耗ATP。鈣在腸道的吸收受很多因素影響，如維生素D₃的水平、腸道酸性環(huán)境、年齡、雌激素水平以及日糧纖維攝入等。腸道吸收的鈣離子，通過門靜脈進(jìn)入血液，被運輸?shù)礁鱾€器官，包括在骨骼上的沉積。而檸檬酸主要在肝臟、肌肉和腎臟中通過三羧酸循環(huán)被分解利用，最終為機(jī)體提供能量。檸檬酸鈣主要通過在胃環(huán)境中分解出的檸檬酸實現(xiàn)更多的功能。檸檬酸經(jīng)三羧酸循環(huán)，最終生產(chǎn)二氧化碳和水，并產(chǎn)生ATP，為機(jī)體提供能量，促進(jìn)機(jī)體生長發(fā)育。檸檬酸鈣在胃環(huán)境中分解出檸檬酸，可降低胃腸道pH值，有利于激活胃蛋白酶原。檸檬酸鈣對腸胃無刺激作用，可不經(jīng)胃酸中和而直接被機(jī)體吸收，吸收率高。檸檬酸鈣本身的溶解性優(yōu)于碳酸鈣、磷酸鈣、硫酸鈣等其他鈣源，降解過程中可高效、平穩(wěn)釋放鈣離子。

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抗壞血酸錳Manganese Ascorbate、抗壞血酸亞鐵Ferrous Ascorbate、賴氨酸甘氨酸鎂Magnesium Lysinate Glycinate、甘氨酸谷氨酰胺鎂Magnesium Glycinate Glutamine、檸檬酸蘋果酸鎂Magnesium Citrate Malate、檸檬酸鍶Strontium Citrate、檸檬酸錳Manganese Citrate、檸檬酸銅Copper Citrate、天門冬氨酸鋰Lithium Aspartate、?；撬嵛?/span>Selenium Taurate.

Metabolism of calcium citrate in the body

Calcium absorption occurs mainly in the small intestine through two pathways, paracellular pathway and transcellular pathway regulated by vitamin D3, through Ca2+ transporters on transmembrane proteins. Paracellular pathway is an absorption pathway that uses the gradient of calcium ion concentration in the intestine and blood to carry out passive transport without consuming ATP. The transcellular pathway is a process in which calcium ions are actively absorbed by the body through calcium-binding proteins and dependent on vitamin D3 under the action of related enzymes, which requires the consumption of ATP. The absorption of calcium in the gut is influenced by many factors, such as vitamin D3 levels, intestinal acidic environment, age, estrogen levels, and dietary fiber intake. Calcium ions absorbed by the gut, which enter the bloodstream through the portal vein, are transported to various organs, including deposits on the bones. Citric acid is mainly broken down and utilized in the liver, muscles and kidneys through the tricarboxylic acid cycle, and ultimately provides energy for the body. Calcium citrate mainly achieves more functions by breaking down citric acid in the stomach environment. Citric acid through the tricarboxylic acid cycle, and eventually produce carbon dioxide and water, and produce ATP, to provide energy for the body, promote body growth and development. Calcium citrate breaks down citric acid in the gastric environment, reduces gastrointestinal pH, and is conducive to the activation of pepsinogen. Calcium citrate has no irritating effect on the stomach and is directly absorbed by the body without being neutralized by stomach acid, with high absorption rate. The solubility of calcium citrate itself is better than other calcium sources such as calcium carbonate, calcium phosphate and calcium sulfate, and calcium ions can be released efficiently and smoothly during the degradation process.

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Manganese Ascorbate, Ferrous Ascorbate, Magnesium Lysinate Glycinate, Magnesium glutamine Glycinate Glutamine, Magnesium Citrate Malate, Strontium Citrate, Manganese Citrate, Copper Citrate, Lithium aspartate Aspartate, Selenium Taurate.