氨基酸螯合鈣（Amino acid chelate calcium）對人體的影響

氨基酸螯合物是1個或多個氨基酸基團與可溶性的金屬鹽中的金屬離子發(fā)生配合反應(yīng)形成的具有環(huán)狀結(jié)構(gòu)的化合物。氨基酸螯合鈣的吸收機理是以整個分子被腸粘膜細胞主動吸收，吸收入血后，以螯合物形式持續(xù)解離出Ca²⁺供機體利用，避免了血鈣過高導(dǎo)致的腎排Ca²⁺ 量增加或高鈣血癥，保證了鈣的充分吸收及利用。這種緩慢釋放不引起機體調(diào)節(jié)穩(wěn)定系統(tǒng)產(chǎn)生反射性抑制作用，屬于不飽和吸收過程。有機酸鈣產(chǎn)品的吸收率略高于無機鈣產(chǎn)品，氨基酸螯合鈣制劑的吸收率明顯高于前兩者。雖然氨基酸螯合鈣的吸收機制明顯的優(yōu)于無機和傳統(tǒng)有機酸鈣制劑，但也不能證明其不具有潛在安全問題。吸收率高及不飽和吸收過程并不代表其長期服用對其他代謝途徑、生理功能不產(chǎn)生負面影響，甚至具有致畸致突變的潛在安全隱患。然而人體對每種必需氨基酸的需求是有一定數(shù)量和比例要求的，人體若長期攝入組成比例不平衡的必需氨基酸，可能會使體內(nèi)產(chǎn)生負氮平衡。不過迄今為止，還沒有發(fā)現(xiàn)其具有急性毒性及致突變性。

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The effect of Amino acid chelate calcium on the human body

Amino acid chelates are compounds with ring structure formed by the reaction of one or more amino acid groups with metal ions in soluble metal salts. The absorption mechanism of amino acid chelated calcium is that the whole molecule is actively absorbed by intestinal mucosal cells, and after absorption into the blood, the Ca2+ is continuously dissociated in the form of chelate for the body to use, avoiding the increase of renal Ca2+ or hypercalcemia caused by excessive blood calcium, and ensuring the full absorption and utilization of calcium. This slow release does not cause reflective inhibition in the body's regulatory stability system, which belongs to the unsaturated absorption process. The absorption rate of organic calcium products was slightly higher than that of inorganic calcium products, and the absorption rate of amino acid chelated calcium preparations was significantly higher than the first two. Although the absorption mechanism of amino acid chelated calcium is clearly superior to inorganic and conventional organic calcium acid preparations, it does not prove that it does not have potential safety concerns. The high absorption rate and unsaturated absorption process do not mean that its long-term use will not have negative effects on other metabolic pathways and physiological functions, and even have potential safety hazards of teratogenicity and mutation. However, the human body needs a certain number and proportion of each essential amino acid, if the human body long-term intake of the proportion of essential amino acids is not balanced, it may cause the body to produce negative nitrogen balance. However, so far, no acute toxicity and mutagenicity have been found.

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