檸檬酸鍶Strontium Citrate對(duì)缺氧/復(fù)氧誘導(dǎo)的心肌細(xì)胞損傷的影響

心肌損傷是由于心臟I/R造成，長(zhǎng)期I/R損傷可能引發(fā)DNA損傷、細(xì)胞功能障礙和細(xì)胞死亡，可導(dǎo)致急性冠脈綜合征和心肌梗死,嚴(yán)重威脅病人的生命健康。檸檬酸鹽（檸檬酸鍶Strontium Citrate）是一種重要代謝產(chǎn)物，不僅可以作為膽固醇與細(xì)胞質(zhì)合成脂肪酸的碳源，還可以促進(jìn)線粒體能量代謝，使用其預(yù)處理可以有效降低心肌細(xì)胞凋亡, 有研究表明，檸檬酸鹽（檸檬酸鍶Strontium Citrate）具有抑制新鮮血液凝固的作用，在臨床采血中被用作抗凝血?jiǎng)?，并有?bào)道指出其可以起保護(hù)心肌的作用，有效抑制心肌細(xì)胞凋亡;在心肌細(xì)胞研究中，檸檬酸鹽（檸檬酸鍶Strontium Citrate）展現(xiàn)出獨(dú)特作用。當(dāng)心肌細(xì)胞經(jīng)歷缺氧/復(fù)氧過程時(shí)，往往會(huì)遭受嚴(yán)重?fù)p傷。而檸檬酸鍶（Strontium Citrate）能通過多種機(jī)制發(fā)揮保護(hù)作用。它可以調(diào)節(jié)細(xì)胞內(nèi)離子平衡，減少因缺氧/復(fù)氧導(dǎo)致的鈣超載現(xiàn)象，降低心肌細(xì)胞的興奮性，維持其正常的電生理活動(dòng)。同時(shí)，檸檬酸鍶（Strontium Citrate）可能具有抗氧化作用，清除自由基，減輕氧化應(yīng)激對(duì)心肌細(xì)胞的損害。此外，它還可能參與細(xì)胞信號(hào)傳導(dǎo)通路的調(diào)節(jié)，促進(jìn)心肌細(xì)胞的存活和修復(fù)，為防治心肌缺血再灌注損傷提供了新的思路和方向

檸檬酸鍶Strontium Citrate對(duì)缺氧/復(fù)氧誘導(dǎo)的心肌細(xì)胞損傷的影響

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Effect of Strontium Citrate on hypoxia/reoxygenation-induced cardiomyocyte injury

Myocardial injury is caused by cardiac I/R, and long-term I/R damage may lead to DNA damage, cell dysfunction and cell death, which can lead to acute coronary syndrome and myocardial infarction, which seriously threatens the life and health of patients. Citrate (Strontium Citrate) is an important metabolite, which can not only be used as a carbon source for the synthesis of fatty acids from cholesterol and cytoplasm, but also promote mitochondrial energy metabolism. Studies have shown that citrate (Strontium Citrate) has the effect of inhibiting the clotting of fresh blood, and is used as an anticoagulant in clinical blood collection. It has also been reported that it can play a protective role in myocardium and effectively inhibit cardiomyocyte apoptosis; In cardiomyocyte research, citrate (Strontium Citrate) exhibits a unique role. When cardiomyocytes undergo a hypoxia/reoxygenation process, they tend to suffer severe damage. Strontium Citrate, on the other hand, exerts a protective effect through a variety of mechanisms. It can regulate intracellular ion balance, reduce calcium overload caused by hypoxia/reoxygenation, reduce the excitability of cardiomyocytes, and maintain their normal electrophysiological activities. At the same time, Strontium Citrate may have antioxidant effects, scavenge free radicals, and reduce oxidative stress damage to cardiomyocytes. In addition, it may also participate in the regulation of cell signaling pathways, promote the survival and repair of cardiomyocytes, and provide new ideas and directions for the prevention and treatment of myocardial ischemia-reperfusion injury

Effect of Strontium Citrate on hypoxia/reoxygenation-induced cardiomyocyte injury

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