鋅離子（甘氨酸鋅Zinc Glycinate、L-天門冬氨酸鋅Zinc Aspartate 、乳清酸鋅Zinc Orotate、抗壞血酸鋅Zinc Ascorbate、葡萄糖酸鋅Zinc Gluconate、檸檬酸鋅Zinc Citrate、蘋果酸鋅Zinc Malate、吡啶甲酸鋅Zinc Picolinate）的抗炎作用機制

鋅是公認的抗氧化劑與抗炎劑，在體內平衡、免疫功能、氧化應激、細胞凋亡和衰老中起著至關重要的作用。鋅是人體必需的微量元素之一，其作為機體300多種酶的輔酶，參與機體DNA、RNA 及蛋白質的合成，可影響生物膜的穩(wěn)定性和多蛋白復合物的排列，調節(jié)激素及其受體的形成，當機體缺鋅，不僅影響免疫狀態(tài)，增加氧化應激，還會導致炎癥的發(fā)生。 鋅可以影響許多炎癥細胞因子的產生和信號傳遞，在體外可增強單核細胞對內皮細胞的黏附，并對促炎細胞因子的產生具有不利影響。缺鋅會引起對脂多糖的過度炎癥反應，加重多微生物膿毒血癥小鼠的全身炎癥反應和膿毒血癥誘導的器官損傷易感性，增加肺組織中炎性細胞因子表達，這種炎性細胞因子的表達水平或與血清鋅濃度呈現(xiàn)負相關趨勢。鋅缺乏除了導致炎性細胞因子分泌增多以外，還可加劇中性粒細胞遷移及上調趨化因子表達。從這些相似的研究結果可以看出，缺鋅使宿主各種促炎細胞因子增加，加重炎癥反應，而補充鋅可在一定程度上逆轉該過程。類似的，鋅的加入可顯著改善小鼠急性炎癥反應，仔豬腸道感染，一定程度上可代替抗生素的使用，是臨床抗炎劑的潛在候選者，前景廣闊。

鋅離子（甘氨酸鋅Zinc Glycinate、L-天門冬氨酸鋅Zinc Aspartate 、乳清酸鋅Zinc Orotate、抗壞血酸鋅Zinc Ascorbate、葡萄糖酸鋅Zinc Gluconate、檸檬酸鋅Zinc Citrate、蘋果酸鋅Zinc Malate、吡啶甲酸鋅Zinc Picolinate）的抗炎作用機制

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甘氨酸鈣Calcium Glycinate、葡萄糖酸錳Manganese Gluconate、富馬酸亞鐵Ferrous Fumarate、天門冬氨酸鎂Magnesium Aspartate、氨基酸螯合銅Copper Amino Acid Chelate、賴氨酸鎂Magnesium Lysinate、L-酪氨酸L-Tyrosine、L-半胱氨酸L-Cysteine、L-鳥氨酸鹽酸鹽L-Ornithine Hydrochloride、蘋果酸鈣Calcium Malate

Anti-inflammatory mechanism of zinc ion（Zinc Glycinate、Zinc Aspartate 、Zinc Orotate、Zinc Ascorbate、Zinc Gluconate、Zinc Citrate、Zinc Malate、Zinc Picolinate）

Zinc is a recognized antioxidant and anti-inflammatory agent that plays a vital role in homeostasis, immune function, oxidative stress, apoptosis and aging. Zinc is one of the essential trace elements in the human body. As a coenzyme of more than 300 enzymes in the body, it is involved in the synthesis of DNA, RNA and protein in the body, which can affect the stability of biofilm and the arrangement of multi-protein complexes, and regulate the formation of hormones and their receptors. When the body is deficient in zinc, it will not only affect the immune state, increase oxidative stress, but also lead to inflammation. Zinc can affect the production and signaling of many inflammatory cytokines, enhance the adhesion of monocytes to endothelial cells in vitro, and adversely affect the production of pro-inflammatory cytokines. Zinc deficiency can cause excessive inflammatory response to lipopolysaccharide, aggravate systemic inflammatory response and susceptibility to sepsis induced organ damage in mice with multimicrobial sepsis, and increase the expression of inflammatory cytokines in lung tissue, which may be negatively correlated with serum zinc concentration. In addition to the increased secretion of inflammatory cytokines, zinc deficiency can also increase neutrophil migration and up-regulate the expression of chemokines. From these similar results, it can be seen that zinc deficiency increases various proinflammatory cytokines in the host and aggravates the inflammatory response, and zinc supplementation can reverse this process to a certain extent. Similarly, the addition of zinc can significantly improve the acute inflammatory response of mice and intestinal infection of piglets, and can replace the use of antibiotics to a certain extent, which is a potential candidate for clinical anti-inflammatory agents with broad prospects.

Anti-inflammatory mechanism of zinc ion（Zinc Glycinate、Zinc Aspartate 、Zinc Orotate、Zinc Ascorbate、Zinc Gluconate、Zinc Citrate、Zinc Malate、Zinc Picolinate）

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Calcium Glycinate；Manganese Gluconate；Ferrous Fumarate；Magnesium Aspartate；Copper Amino Acid Chelate；Magnesium Lysinate；L-Tyrosine；L-Cysteine；L-Ornithine Hydrochloride；Calcium Malate